Abstract
AbstractMetabolomics offers a promising approach to studying metabolites in the biological system. It offers new opportunities to assess the disease progression and biomarker selection and also provides a pathophysiological understanding of the disease. Autoimmune liver disease is a major public health concern worldwide. Three main categories of this disease include autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC). Their pathogenesis is poorly understood till now. If not treated properly then it will eventually lead to liver cirrhosis and ultimately liver failure occurs. This review summarizes a comprehensive overview of human and animal studies intended to identify the role of metabolomics in all three types of autoimmune liver disease so far. Furthermore, a detailed discussion has been carried out on the disturbed metabolic pathways, including carbohydrate, amino acid, fatty acids, lipids, and bile acid metabolism. Till now, limited work has been done regarding the diagnostic assessment, type of therapy, and disease management for each type. Further research should be conducted to grasp this disease at an earlier stage and to prevent disease‐related complications.
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