Abstract
The beneficial effects of exercise in patients with type 1 diabetes (T1D) are not fully proven, given that it may occasionally induce acute metabolic disturbances. Indeed, the metabolic disturbances associated with sustained exercise may lead to worsening control unless great care is taken to adjust carbohydrate intake and insulin dosage. In this work, pre- and post-exercise metabolites were analyzed using a 1H-NMR and GC-MS untargeted metabolomics approach assayed in serum. We studied ten men with T1D and eleven controls matched for age, body mass index, body fat composition, and cardiorespiratory capacity, participated in the study. The participants performed 30 minutes of exercise on a cycle-ergometer at 80% VO2max. In response to exercise, both groups had increased concentrations of gluconeogenic precursors (alanine and lactate) and tricarboxylic acid cycle intermediates (citrate, malate, fumarate and succinate). The T1D group, however, showed attenuation in the response of these metabolites to exercise. Conversely to T1D, the control group also presented increases in α-ketoglutarate, alpha-ketoisocaproic acid, and lipolysis products (glycerol and oleic and linoleic acids), as well as a reduction in branched chain amino acids (valine and leucine) determinations. The T1D patients presented a blunted metabolic response to acute exercise as compared to controls. This attenuated response may interfere in the healthy performance or fitness of T1D patients, something that further studies should elucidate.
Highlights
Type 1 diabetes mellitus (T1D) is a lifelong metabolic disorder of usual acute onset in children, adolescents and young adult people
In ten patients with T1D and eleven controls matched for age, height, weight, and body mass index (BMI), no differences were found in relation to the percentage of body fat composition and cardio respiratory capacity evaluated by VO2max
Our findings revealed similar metabolic events in T1D patients and their control matched exercisers, the T1D patients showed an attenuation of overall metabolic response after intense short-term exercise
Summary
Type 1 diabetes mellitus (T1D) is a lifelong metabolic disorder of usual acute onset in children, adolescents and young adult people. Micro and macro vascular co-morbidities develop in patients with T1D which are closely related to metabolic control [1]. In addition to these complications, the management of T1D is complex and challenging. The beneficial effects of exercise in patients with T1D are not fully proven, given that exercise may occasionally induce acute metabolic disturbances, mainly related to insulin treatment. Children and adolescents with T1D are encouraged to exercise regularly as a means of improving social integration and cardiovascular health [8]. A better understanding of the effects of exercise on the metabolic response in T1D patients will allow clinicians to prescribe exercise to their patients with greater clarity
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
