Abstract
Background: It is well known that obesity induced by high-fat diet (HFD) poses a serious threat to people’s health. Fuzhuan brick tea, one of the most popular beverages, is reported to possess a significant effect on regulating lipid metabolism, attributed to its many bioactive ingredients. However, the efficacy and mechanism of compound Fuzhuan brick tea (CFBT) made from Fuzhuan brick tea and other six Chinese herbal medicines are still not well defined. Methods: Sixty mice were divided into six groups: normal control group (CK), high-fat model group (NK), positive control group with anti-hyperlipidemic drug (YK), CFBT at low-(FL), medium-(FM) and high-(FH) dosage. Intervening for 30 days, conventional indexes analysis combined with metabolomics were performed to evaluate the changes in biochemical indexes and liver metabolic profiles in mice submitted to HFD. Results: CFBT treatment was able to ameliorate obesity, serum biochemical parameters, antioxidant activity and hepatic steatosis. In addition, significant alterations in the liver tissue metabolic profiles were observed, with most of these associated with inflammation, glucose and lipid metabolism. Conclusions: This study provides evidence that consumption of CFBT is capable of preventing dyslipidemia, reducing weight gain, restoring liver injury, as well as improving metabolic disorders.
Highlights
The continuous ingestion of a high-energy and high-fat diet (HFD) may cause harmful activation of the immune system and induce lipid metabolism disorder, which may lead to chronic metabolic diseases such as diabetes, hypertension, cardiovascular disease and obesity [1,2]
TphreevreensutilntsgshwoewigehdtthgaatinCFwBaTsamndorXeuoebzhviikoaunsgwcaitphsuthlee incretareseatimnednot swaegreeoafblCeFtoBTp.revent the increase in body weight and liver weight in mice, and the effect of preventing weight gain was more obvious with the increase in dosage of compound Fuzhuan brick tea (CFBT)
In NK vs. FH group, we found that tauroursodeoxycholic acid, taurochenodesoxycholic acid, glycoursodeoxycholic acid, D-sorbitol, D-fructose, D-galactose, D-glucose, D-mannose, D-sucrose, and D-trehalose, etc. were significantly down-regulated and most chemical compounds in the the FH group: eicosapentaenoic acid, eicosatetraenoic acid, docosahexaenoic acid, and 12-hydroxyeicosane tetraenoic acid, were significantly up-regulated compared to the NK group, which were annotated in the pathways of starch and sucrose metabolism, phosphotransferase system (PTS), galactose metabolism, fructose and mannose metabolism, carbohydrate digestion and absorption and AMPK signaling pathway (Figure 6B)
Summary
The continuous ingestion of a high-energy and high-fat diet (HFD) may cause harmful activation of the immune system and induce lipid metabolism disorder, which may lead to chronic metabolic diseases such as diabetes, hypertension, cardiovascular disease and obesity [1,2]. The disorder of fat metabolism in obese individuals is mainly manifested by the increase in plasma free fatty acids, cholesterol, triglycerides, total fat and other lipid profiles. Obese patients are usually accompanied by high blood lipids. There are two types of hyperlipidemias: primary hyperlipidemia is related to genetic factors and abnormalities of enzymes, receptors or apolipoproteins involved in lipoprotein metabolism and transport due to genetic defects; secondary hyperlipidemia is mostly caused by metabolic disorders (diabetes, obesity, hypertension, liver and kidney diseases, etc.). It is well known that obesity induced by high-fat diet (HFD) poses a serious threat to people’s health. Conclusions: This study provides evidence that consumption of CFBT is capable of preventing dyslipidemia, reducing weight gain, restoring liver injury, as well as improving metabolic disorders
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
