Abstract
BackgroundIrritable bowel syndrome (IBS) is a common functional gastrointestinal disorder, which is commonly treated with antidiarrhoeal, antispasmodics, serotonergic agents or laxative agents. These treatments provide relief for IBS symptoms but may also lead to undesired side effects. Previously, herb-partitioned moxibustion (HPM) treatment has been demonstrated to be effective in ameliorating symptoms of IBS. However, the underlying mechanism of this beneficial treatment is yet to be established. The aim of the current study was to systematically assess the metabolic alterations in response to diarrhea-predominant IBS (IBS-D) and therapeutic effect of HPM.MethodsProton nuclear magnetic resonance spectroscopy (1H NMR)-based metabolomics approach was used to investigate fecal and serum metabolome of rat model of IBS-D with and without HPM treatment.ResultsThe current results showed that IBS-induced metabolic alterations in fecal and serum sample include higher level of threonine and UDP-glucose together with lower levels of aspartate, ornithine, leucine, isoleucine, proline, 2-hydroxy butyrate, valine, lactate, ethanol, arginine, 2-oxoisovalerate and bile acids. These altered metabolites potentially involve in impaired gut secretory immune system and intestinal inflammation, malabsorption of nutrients, and disordered metabolism of bile acids. Notably, the HPM treatment was found able to normalize the Bristol stool forms scale scores, fecal water content, plasma endotoxin level, and a number of IBS-induced metabolic changes.ConclusionsThese findings may provide useful insight into the molecular basis of IBS and mechanism of the HPM intervention.
Highlights
Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder, which is commonly treated with antidiarrhoeal, antispasmodics, serotonergic agents or laxative agents
We focused on the changes in body metabolism induced by moxibustion on the diarrhea-predominant irritable bowel syndrome (IBS-D) model
By comparing the herb-partitioned moxibustion (HPM) and normal control (NC) rats, there are no group significant difference in Bristol Stool Form (BSF) and Fecal water content (FWC), suggesting HPM treatment is efficient in alleviating diarrhea symptoms
Summary
Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder, which is commonly treated with antidiarrhoeal, antispasmodics, serotonergic agents or laxative agents. These treatments provide relief for IBS symptoms but may lead to undesired side effects. Herb-partitioned moxibustion (HPM) treatment has been demonstrated to be effective in ameliorating symptoms of IBS. Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder [1] characterized by stomachache, abdominal distension and altered bowl evacuation habit, along with abnormal fecal character [2]. Among the TCM treatments, herb-partitioned moxibustion (HPM) is a characteristic external therapy that has been repeatedly found to confer curative effect in ameliorating IBS symptoms [8]. The therapeutic mechanism of HPM on IBS is still unknown
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