Abstract
Identification of novel PPARγ agonist from GC-MS analysis of ethanolic extract of Cayratia trifolia (L.): a computational molecular simulation studiesPalanisamy CHELLA PERUMAL, Sundaram SOWMYA, Prabhakaran PRATIBHA, Balasubramanian VIDYA, Palanirajan ANUSOORIYA, Thangarajan STARLIN, Ramasamy VASANTH, D. JEYA SUNDRA SHARMILA, Velliyur Kanniappan GOPALAKRISHNAN
Highlights
Endometriosis has been known as the most frequent cause of pelvic pain in women during reproductive years
The reason is that the estrogen level in the eutopic endometrium of women with endometriosis is higher than in normal endometrium which may possibly be caused by the lack of interaction between progesterone and progesterone receptor (PR)
We investigated the bioactive compounds of DLBS1442 that may act as a PR agonist and evaluated its molecular activity
Summary
Endometriosis has been known as the most frequent cause of pelvic pain in women during reproductive years. Progesterone exerts an antiestrogenic effect, in part by inducing 17β-hydroxysteroid dehydrogenase 2 (HSD17β2) which catalyzes the conversion of biologically potent estradiol to much less estrogenic estrone (Bulun et al, 2006). The estrogen level in the eutopic endometrium in women with endometriosis is higher than in normal endometrium, which may possibly be caused by the lack of interaction between progesterone and PR. As previously stated by Bulun et al (2006), the increase of estrogen level in endometrial tissue is caused by progesterone resistance.
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