Metabolomic Studies in Inner Ear Pathologies.

Luc Boullaud,Thuy-Trân Trinh,David Bakhos,Hélène Blasco

doi:10.3390/metabo12030214

Luc Boullaud, Thuy-Trân Trinh + Show 2 more

Open Access

https://doi.org/10.3390/metabo12030214

Copy DOI

Journal: Metabolites	Publication Date: Feb 26, 2022
Citations: 6	License type: CC BY 4.0

Affiliation: Université de Tours, Inserm, House Clinic

Abstract

Sensorineural hearing loss is the most common sensory deficit. The etiologies of sensorineural hearing loss have been described and can be congenital or acquired. For congenital non-syndromic hearing loss, mutations that are related to sites of cochlear damage have been discovered (e.g., connexin proteins, mitochondrial genes, etc.). For cytomegalovirus infection or auditory neuropathies, mechanisms are also well known and well researched. Although the etiologies of sensorineural hearing loss may be evident for some patients, the damaged sites and pathological mechanisms remain unclear for patients with progressive post-lingual hearing loss. Metabolomics is an emerging technique in which all metabolites present in a sample at a given time are analyzed, reflecting a physiological state. The objective of this study was to review the literature on the use of metabolomics in hearing loss. The findings of this review suggest that metabolomic studies may help to develop objective tests for diagnosis and personalized treatment.

Highlights

Sensorineural hearing loss (SNHL) is the most common sensory deficit and a major public health problem [1]
This systematic literature review was conducted by searching medical literature analysis and retrieval system online (MEDLINE; PubMed interface), Excerpta Medical dataBASE (EMBASE; Elsevier interface), Cochrane Central Register of Controlled Trials (CENTRAL; Wiley interface), International Standard Randomised Controlled Trial
The results suggest an important role for glutamate in the pathophysiology of SNHL due to synaptopathy following acoustic trauma

Summary

Introduction

Sensorineural hearing loss (SNHL) is the most common sensory deficit and a major public health problem [1]. It is estimated that hearing loss affects approximately 466 million people worldwide, or 5% of the world’s population, and 34 million of these are children. Estimates show that by 2050, 900 million people will have disabling hearing loss, representing one-tenth of the world’s population SNHL is a chronic disease that can affect oral language development [2], education, and social interaction. It impairs one’s quality of life by reducing social and professional relationships and communication. SNHL may result from damage between the cochlea and the auditory cortex. It can be attributed to endocochlear lesions, neural impairment (e.g., neuropathy or vestibular schwannoma), or central hearing loss. Endocochlear damage is thought to be the leading cause of SNHL

Objectives

Methods

Discussion

Conclusion