Abstract
Purpose: Metabolomic analysis holds great potential for improving the understanding about osteoarthritis (OA) caused metabolomic shifts associated with systemic inflammation and oxidative stress (OxS). Amino acids and polyamines are closely involved in maintaining the balance between reactive oxygen species (ROS) and antioxidant system. The main aim of the study was to map the systemic changes of amino acids and polyamines in the severe OA compared with asymptomatic matched controls and identify systemic serum biomarkers that have the potential to be used in clinical practise.
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