Abstract
Lung cancer continues to be a significant burden worldwide and remains the leading cause of cancer-associated mortality. Two considerable challenges posed by this disease are the diagnosis of 61% of patients in advanced stages and the reduced five-year survival rate of around 4%. Noninvasively collected samples are gaining significant interest as new areas of knowledge are being sought and opened up. Metabolomics is one of these growing areas. In recent years, the use of metabolomics as a resource for the study of lung cancer has been growing. We conducted a systematic review of the literature from the past 10 years in order to identify some metabolites associated with lung cancer. More than 150 metabolites have been associated with lung cancer-altered metabolism. These were detected in different biological samples by different metabolomic analytical platforms. Some of the published results have been consistent, showing the presence/alteration of specific metabolites. However, there is a clear variability due to lack of a full clinical characterization of patients or standardized patients selection. In addition, few published studies have focused on the added value of the metabolomic profile as a means of predicting treatment response for lung cancer. This review reinforces the need for consistent and systematized studies, which will help make it possible to identify metabolic biomarkers and metabolic pathways responsible for the mechanisms that promote tumor progression, relapse and eventually resistance to therapy.
Highlights
Lung cancer is still a burden in modern societies [1], and remains the leading cause of death by cancer worldwide
The methodological quality score was calculated based on three domains: Selection, Comparability, and Exposure
Higher concentrations of several amino acids, such as valine, leucine and isoleucine, are usually detected during the development of lung cancer. Increased levels of these amino acids are required for energy production through the Krebs cycle
Summary
Lung cancer is still a burden in modern societies [1], and remains the leading cause of death by cancer worldwide. With 2.2 million new cases in 2020, or 12% of all diagnosed cancers, it is the second most commonly diagnosed form of the disease. Despite a small decline in the Western world, lung cancer incidence and mortality statistics are still increasing. Smoking is one of the main risk factors, accounting for 25% of cases, 15% of lung cancers in men and 53% in women are not smoking-related [2]. When the cancer is diagnosed at an early stage, the five-year survival of patients is about 50%. More than 61% of patients are diagnosed in later stages (III and IV), when therapeutic options are limited. In this setting, the five-year survival can be as low as
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
