Abstract

Pre‐deployment identification of risk and resilience factors is crucial in developing targets to reduce or prevent posttraumatic stress symptoms in military personnel. The Fort Campbell Cohort study was designed to assess pre‐deployment biological and behavioral markers and build predictive models to identify risk and resistance for posttraumatic stress disorder (PTSD) following deployment. The aim of the current study was to use high‐resolution metabolomics profiling to identify metabolic pathways and networks associated with PTSD checklist score differences and changes across multiple pre and post‐deployment time points. In addition, we have investigated how deployment affects metabolomics profile changes within individuals independent of PTSD score changes. Untargeted metabolomics profiling of plasma has been completed using both liquid and gas chromatography with mass spectrometry. Our preliminary data indicates that deployment has complex metabolic effects that must be considered in evaluation of deployment‐associated exposures in military personnel. Our in depth‐data analysis may further elucidate pathways, novel compounds, and biomarkers associated with PTSD in its relation to military deployment. These findings may have clinical implications for understanding the pathogenesis of PTSD and provide insights to avert chronic PTSD.Disclaimers: Research was conducted in compliance with all Federal requirements. The views expressed are those of the authors and do not constitute endorsement by the U.S. ArmySupport or Funding InformationFunding support from Military Operational Medicine Research Program, MOMRP is highly acknowledged.This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.

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