Abstract
Marine microorganisms are an important source of natural products with potent bioactivities. Unlike the land, the ocean, especially the deep-sea, is characterized by high pressure, high salinity, low nutrition, and no light among others. Therefore, the biodiversity of marine microorganisms is supposed to be very different from that of the terrestrial ones. Yet, many marine microorganisms can find their counterparts in terrestrial environments. To evaluate their differences, a comparative metabolomics investigation was performed on four strains of Nesterenkonia flava isolated from terrestrial and marine environments. As a result, marine strains were clearly distinguished from terrestrial ones on the principal components analysis (PCA) score plot. Furthermore, by partial least squares discrimination analysis (PLS-DA) and univariate analysis, the characteristic metabolites were figured out and found to be involved in osmotic regulation, redox balancing, and energy metabolism. Our results demonstrated that marine actinomycetes could produce novel secondary metabolites different from their terrestrial relatives because they have special metabolic patterns closely related to the unique features of their living environment.
Highlights
During the past few decades, natural products have played a dominant role in discovery of drugs for the treatment of various diseases [1]
Of the intracellular metabolites from were performed four stains of N. flava, strains wereanalysis located together, discriminating that of on the terrestrial one including on the first princip one terrestrial (Land) and three marine strains (Marine-1–Marine-3)
Since the metabolite profiles of microorganisms can b strains were located together, discriminating from that of the terrestrial one on the first principal affected by component the medium applied, another different culture media were adopted for furth of the score plot
Summary
During the past few decades, natural products have played a dominant role in discovery of drugs for the treatment of various diseases [1]. These disagreements make it more difficult to 2 ofevaluate soils could be into to wh extent marine microbes are evolutionarily, ecologically, or chemically distinct from their terrestri coverstool, moremetabolomics than 70% of the Earth’s surface. Nesterenkonia is an important ofdisagreements the Micrococcaceae family of 12 species [17 in soils could be washed into thegenus sea These make it more difficult consisting to evaluate to what extent marine microbes are evolutionarily, ecologically, or chemically actinomycetes distinct from their terrestrial. They are halophilic/halotolerant and alkaliphilic/alkalitolerant occurring around th relatives [11,12]. Nesterenkonia is an important genus of the Micrococcaceae family consisting of 12 species [17]
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