Abstract
Sarcoidosis is a disorder characterized by granulomatous inflammation of unclear etiology. In this study we evaluated whether veterans with sarcoidosis exhibited different plasma metabolomic and metallomic profiles compared with civilians with sarcoidosis. A case control study was performed on veteran and civilian patients with confirmed sarcoidosis. Proton nuclear magnetic resonance spectroscopy (1H NMR), hydrophilic interaction liquid chromatography mass spectrometry (HILIC-MS) and inductively coupled plasma mass spectrometry (ICP-MS) were applied to quantify metabolites and metal elements in plasma samples. Our results revealed that the veterans with sarcoidosis significantly differed from civilians, according to metabolic and metallomics profiles. Moreover, the results showed that veterans with sarcoidosis and veterans with COPD were similar to each other in metabolomics and metallomics profiles. This study suggests the important role of environmental risk factors in the development of different molecular phenotypic responses of sarcoidosis. In addition, this study suggests that sarcoidosis in veterans may be an occupational disease.
Highlights
Sarcoidosis is a granulomatous entity of unknown etiology
We evaluated whether veterans with sarcoidosis have a different metabolomic and metallomic profile compared to other veterans with a non-sarcoidosis pulmonary condition, (COPD)
This study shows that veterans with sarcoidosis have distinct metabolomic and metallomic profiles when compared to civilians with sarcoidosis
Summary
Sarcoidosis is a granulomatous entity of unknown etiology. The incidence of sarcoidosis has been well studied in the American civilian population and ranges between 11 in 100,000 in Caucasians to up to 36 in 100,000 in African American populations[1]. Metabolomics is a method to identify and measure small molecules – metabolites – which may provide a way to study and monitor disease progression. Metabolomics has helped to identify potential biomarkers for the diagnosis and prognosis of infectious and non-infectious respiratory conditions such as asthma[6], chronic obstructive pulmonary disease (COPD)[7,8], influenza[9], pneumonia[10], tuberculosis[11], and acute respiratory distress syndrome (ARDS)[12,13]. We sought to evaluate whether veterans with sarcoidosis exhibit different metabolomics and metallomics profiles compared with civilians with sarcoidosis. We evaluated whether veterans with sarcoidosis have a different metabolomic and metallomic profile compared to other veterans with a non-sarcoidosis pulmonary condition, (COPD)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
