Abstract
Fungi residing in mangroves are considered to be a bank of novel bioactive natural products. In the screening for bioactive metabolites from mangrove-derived fungi, the ethyl acetate extract of the fermentation broth of Aspergillus fumigatus JRJ111048, a fungus isolated from the leaves of the mangrove plant Acrostichum specioum endemic to Hainan island, was found to possess insecticidal activity against Spodoptera litura. Bioactivity-guided isolation lead to the discovery of seven metabolites 1–7, including one new anhydride derivative aspergide (1), one new lipid amide 11-methyl-11-hydroxyldodecanoic acid amide (2), and five known compounds; α-ethyl glucoside (3), spiculisporic acid B (4), spiculisporic acid C (5), spiculisporic acid (6), and secospiculisporic acid B (7). Their structures were established by NMR spectroscopic and MS analyses, and by comparison of previously reported data. Insecticidal activity against S. litura and antifungal activity of these compounds were investigated. As a result, the new compound 1 showed potent insecticidal activity against newly hatched larvae of S. litura, and compound 4 displayed weak antifungal activity against Candida albicans.
Highlights
IntroductionMarine-derived fungi, such as species of the genus Aspergillus (Trichocomaceae), are a prolific resource for discovering structurally diverse and biologically active secondary metabolites [1,2,3,4]
Marine-derived fungi, such as species of the genus Aspergillus (Trichocomaceae), are a prolific resource for discovering structurally diverse and biologically active secondary metabolites [1,2,3,4].Owing to their unique ecological environments, mangrove plants, growing in the saline coastal habitats in the tropics and subtropics, are considered to be a promising source of novel endophytic fungi such as Aspergillus spp., which could produce versatile bioactive natural products with novel structures [5,6,7]
Drugs 2017, 15, 381 continuous search for new bioactive natural products from plant endophytic fungi [8,9,10,11,12], and as part of a program to investigate the chemical and biological diversity of the secondary metabolites from the endemic mangrove plants-associated fungi, we found a series of secondary metabolitessesquiterpenes, from the endemic fungi, we found a series of novel novel meroterpenes, andmangrove glycosideplants-associated and furan derivatives with diverse bioactivities meroterpenes, sesquiterpenes, and glycoside and furan derivatives with diverse bioactivities
Summary
Marine-derived fungi, such as species of the genus Aspergillus (Trichocomaceae), are a prolific resource for discovering structurally diverse and biologically active secondary metabolites [1,2,3,4] Owing to their unique ecological environments, mangrove plants, growing in the saline coastal habitats in the tropics and subtropics, are considered to be a promising source of novel endophytic fungi such as Aspergillus spp., which could produce versatile bioactive natural products with novel structures [5,6,7].
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