Abstract
Production of cycloheximide and fungicidin by the producing strainStreptomyces noursei 52/152 was shown to be coupled. Cycloheximide added to the culture medium increased the production of fungicidin, addition of fungicidin caused an increase of the production of cycloheximide. Antibiotic compounds added were degraded in the course of cultivation approximately to the same amount as if produced in control cultures. Cycloheximide added to the culture medium was not transformed to actiphenol. It was suggested that the synthesis of secondary metabolites ofStreptomyces noursei is controlled by mechanisms analogous to repression or allosteric inhibition.
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