Abstract
Critical interpretation of toxicology and residue studies on an insecticide chemical is possible only when the metabolism of the compound is understood. Biologically active metabolites may be formed, particularly if the modification on the molecule occurs at a site other than the toxophoric grouping. In this respect, metabolites of carbamates formed by mechanisms other than initial hydrolysis at the carbamic ester site may be of importance. Mammals, and microsomal enzymes of liver, carry out many types of hydroxylation reactions including, among others, aromatic hydroxylation, aliphatic hydroxylation, N-dealkylation, O-de-alkylation, and sulfoxidation (1, 2). Groupings which are potentially susceptible to such hydroxylation reactions are present in methylcarbamate insecticide chemicals.
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