Abstract
Abstract The present study profiled various chemical constituents from the ethyl acetate fraction of Kigelia africana fruit extract in a comparative manner using modern chromatographic methods coupled with mass spectrometric techniques. K. africana plant has a wide usage in folklore medicine for numerous ailments with the ethyl acetate fraction having high antifungal and anti-plasmodial activities. Dried fruits were extracted with ethanol and partitioned using ethyl acetate. The fraction was analyzed using GC–MS, GC-TOF-MS and UHPLC-TOF-MS/MS. Fifteen compounds consisting of 2-methoxy-4-vinylphenol, phenol-2,4-bis(1,1-dimethylethyl), - and 9,12,15-octadecatrienoic acid ethyl ester, (Z, Z, Z) – were obtained from GC–MS while 441 metabolites ranging from flavonoids, cardiac glycosides, and polyphenols were profiled from GC-TOF-MS whereas 235 metabolites were fingerprinted from UHPLC-TOF-MS/MS analysis by measuring m/z values and analyzing MS fragmentation pattern. From the identified phytochemicals through ultra-high-pressure liquid chromatography tandem mass spectrometer (UHPLC-TOF-MS/MS), 14 of them were confirmed and these include gemfibrozil, trimetazidine, and leucomalachite green.
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