Abstract
To determine whether one or both of the sulfur-containing functions of the dithiocarbamate trithiocarbonate (I) of cysteine is responsible for its radioprotective ability, 35S-I was synthesized and its metabolism was studied in mice. The major metabolite was the dithiocarbamate of cystine, which was found in the liver, kidney, and spleen. The protein-bound component was also found in these tissues. Other metabolites found were intact I and possibly cystine in the liver and sulfate in the kidney and spleen. 35S-I was rapidly eliminated, and radioactive compounds which appeared in the urine included the dithiocarbamate, unchanged I, sulfate, and an unidentified substance in small amount.
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