Abstract
The article presents data on the study of the metabolic activity of the intestinal microbiota in children of the first year of life. The study was performed by gas-liquid chromatographic analysis with the determination of short-chain fatty acids (SCFA) in fecal matter, which reflects the microbiota metabolic activity. The content of fecal matter was determined, reflecting the activity of aerobic microbiota-acetic acid (C2); anaerobic microbiota – propionic (C3), butyric (C4) acids; the sum of acids (E); anaerobic index (AI), which is an integral indicator of the intestinal environment. It was found that despite surgical intervention in the intestine in the first months of life, the metabolic activity of microbiota in children with intestinal resection remains stable throughout the first year of life.
Highlights
In recent decades, the development of perinatal medicine and pediatric surgery has improved the survival rate of children who underwent operative therapy during the neonate period
The age characteristics of short-chain fatty acids (SCFA) production are normally not considered in both clinical studies and practical use of SCFA determination method, which can lead to erroneous conclusions regarding the effectiveness of therapeutic interventions and inadequate choice of optimal therapies [6]
The aim of the study was to assess the metabolic activity of the gut microbiota, which is one of the potential markers of biological age; assessment was performed in children of the first year of life who have undergone intestinal resection
Summary
The development of perinatal medicine and pediatric surgery has improved the survival rate of children who underwent operative therapy during the neonate period. Scientific interest in the metabolic function of intestinal microbiota and products of short-chain fatty acids (SCFA) has increased significantly. This is due to the identification of their diverse biological functions that support human health at the systemic level and the potential to influence their concentrations with therapeutic and preventive purposes [1,2,3,4,5]. The age characteristics of SCFA production are normally not considered in both clinical studies and practical use of SCFA determination method, which can lead to erroneous conclusions regarding the effectiveness of therapeutic interventions and inadequate choice of optimal therapies [6]. Research of short-chain fatty acids (SCFA) by gas-liquid chromatographic analysis (GLCA) has high sensitivity and specificity, ease of reproduction, possibility of quick results obtaining [9, 10]
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