Abstract
1. 1. The metabolism of the benzoquinone 2,5-dimethylbenzoquinone and of the naphthoquinone 2,3-dimethoxy-1,4-naphthoquinone was studied in subcellular fractions isolated from cardiac tissue of guinea pig and rat. 2. 2. In both species the benzoquinone was mainly metabolized through the mitochondrial NADH-ubiquinoneoxidoreductase, whereas the naphthoquinone was metabolized to approximately equal extents by mitochondrial reductase and by soluble DT-diaphorase. 3. 3. Guinea pig heart metabolized 3 times more naphthoquinone than rat heart. 4. 4. As a consequence of quinone metabolism, marked amounts of O 2: were generated; naphthoquinoneinduced O 2+: generation was about 4-fold higher in guinea pig than in rat heart.
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