Abstract
The metabolism of prostacyclin (PGI 2) in vivo was investigated in Cynomolgus monkey. Following intravenous infusion of 11-[ 3H]-PGI 2 for three days, pooled urine was extracted with Amberlite XAD-2, then chromatographed and purified by Sephadex LH-20, and reverse phase column chromatography. Radioactive fractions were converted to appropriate derivatives for identification by gas chromatography mass spectrometry. Twelve metabolites were characterized, the major of which was 6-keto-PGF 1α, accounting for 13% of the urinary radioactivity. The metabolic pathways are similar to those observed earlier in the rat. The excretion of substantial amounts of unchanged 6-keto-PGF 1α indicated that the monkey was not able to metabolize PGI 2 as avidly as the rat.
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