Abstract
In situ perfusions using labelled progesterone as substrate were carried out in the human term placenta. Rapid metabolism was demonstrated. The major metabolites isolated in radiochemically pure form were 20α-hydroxypregn-4-en-3-one and 6β-hydroxypregn-4-ene-3,20-dione. Another metabolite was identified tentatively as 5β-pregnane-3,20-dione. No C-18 or C-19 steroids were found. Previous hypotheses have stressed the role of the fetus in the production of certain metabolites identified in umbilical cord blood. It is suggested that placenta I production be considered as well.
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