Abstract
Tetrastigma hemsleyanum Diels et Gilg is a herbaceous perennial species distributed mainly in southern China. The Tetrastigma hemsleyanum root (THR) has been prevalently consumed as a functional tea or dietary supplement. In vitro digestion models, including colonic fermentation, were built to evaluate the release and stability of THR phenolics with the method of HPLC-QqQ-MS/MS and UPLC-Qtof-MS/MS. From the oral cavity, the contents of total phenolic and flavonoid began to degrade. Quercetin-3-rutinoside, quercetin-3-glucoside, kaempferol-3-rutinoside, and kaempferol-3-glucoside were metabolized as major components and they were absorbed in the form of glycosides for hepatic metabolism. On the other hand, the total antioxidant capacity (T-AOC), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activity, and glutathione (GSH) content were significantly increased, while malondialdehyde (MDA) content was decreased in plasma and tissues of rats treated with THR extract in the oxidative stress model. These results indicated that the THR extract is a good antioxidant substance and has good bioavailability, which can effectively prevent some chronic diseases caused by oxidative stress. It also provides a basis for the effectiveness of THR as a traditional functional food.
Highlights
Tetrastigma hemsleyanum Diels et Gilg, a herbaceous perennial species, is distributed mainly in southern China
This result was different from the previous reports, which showed that short-term oral digestion and α-amylase had little effect on the polyphenols, and that oral digestion can be omitted [11,14]
Tetrastigma hemsleyanum root (THR) extract showed higher gastrointestinal digestibility and less reaching the colon; in other words, it may be absorbed in the gastrointestinal tract and have high bioavailability
Summary
Tetrastigma hemsleyanum Diels et Gilg, a herbaceous perennial species, is distributed mainly in southern China. THR has been prevalently consumed as a dietary supplement, nutrient, or health tea for its health benefits. The specific bioactive properties of THR such as immunoregulatory, antioxidant, anti-inflammatory, antipyretic, analgesic, and antiproliferactive capacity have been widely reported. Abundant flavonoids and phenolic acids were found in THR, which may be responsible for their bioactivity above. The phenolics extract from THR showed strong antioxidant activities in several in vitro assay systems (DPPH, FRAP, and ABTS) [3]. The phenolics extract from THR has strong in vitro antioxidant capacity, few studies have reported its in vivo antioxidant effects
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