Abstract
Both naphthalene and 1-naphthol are metabolized by the mixed function oxidase system of housefly microsomes. The biochemical characteristics of naphthalene metabolism parallel those of the N- and O-demethylation reactions studied previously. 1-Naphthol metabolism, on the other hand, deviates from the trends seen with the other two substrates, as some of the 1-naphthol is metabolized by a microsomal enzyme system not associated with the mixed function oxidases, and a considerable amount is lost on incubation with other cell fractions. 1-Naphthol is an inhibitor of both naphthalene hydroxylation and p-nitroanisole demethylation by microsomes. Examination of the kinetics of this reaction show inhibition of the mixed inhibitor type. Inhibition constants as well as I 50 values indicate that both hydroxylation and O-demethylation are equally susceptible to 1-naphthol inhibition.
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