Abstract
Metabolites of lidocaine have been detected in human urine which on reduction with titanious trichloride reagent produced lidocaine and monoethylglycinexylidide (MEGX). It is suggested that the metabolites are the N-hydroxy derivatives of lidocaine and MEGX. Results of comparing the amounts of these metabolites excreted either under conditions of fluctuating urinary pH or acid urinary pH indicate that hydroxylation occurs on the aromatic nitrogen of both lidocaine and MEGX.
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