Abstract
This is a comparative study of the metabolism of radioactive lactic acid in monkeys in profound shock (5 to 8 hours after induction of shock) after attempting resuscitation with Ringer's lactate or Ringer's acetate-gluconate solutions. After infusing Ringer's lactate solution there was depression of lactic acid metabolism. Lactate concentrations were inversely proportional to serum potassium and sodium, indicating fixation of cations. If this model can be extrapolated clinically, Ringer's lactate infusions can be deleterious to patients in prolonged shock.
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