Metabolism of intravneously administered 17 -estradiol-6,7- 3 H-17-glucoside in normal women.

Abstract

17β-Estradiol-6,7-3H-17-glucoside (E2-17-glucoside) was injected iv into two normal young women. Within 72 hr, 61 and 64% of the 3H dose was excreted in the urine in the two experiments. Within 2 hr of injection 0.7 and 1.9% of the dose was excreted as the unchanged glucoside together with 2.5 and 4.4% in the form of a double conjugate, identified with some certainty as E2-3-glucosiduronate-17-glucoside. Between 2 and 4 hr after injection in one subject, and between 2 and 6 hr in the other, a lag in excretion of the label occurred, the small amount of 3H found at these times being in all probability the above double conjugate. No unchanged monoglucoside was detected beyond 2 hr after injectionand no double conjugate was detected with certainty beyond 6 hr. After 4 hr in one subject, and 6 hr in the other, the excretion of label increased markedly. Over the period 6–48 hr in each experiment only monoglucosiduronates were excreted and of these, 74% and 91% were composed of the 3-glucosiduronates of E2 and o...