Abstract
The metabolism of methylprednisolone has been studied in the isolated perfused liver of normal rabbits, pigs, and dogs as well as in dogs that had recovered from hepatic necrosis. A considerable difference in the rate of degradation was noted among the species, the rate being slowest in the rabbit and most rapid in the pig. Previous damage to canine livers that had subsequently recovered resulted in a very moderate decrease in the rate of steroid breakdown. The rate of breakdown of methylprednisolone in the pig approximates most closely that observed in vivo in human volunteers.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
