Metabolism of glucose in first-episode drug-naive patients with schizophrenia and their first-degree relatives

Abstract

Objective To study metabolism of glucose in first-episode drug-naive schizophrenia and their first-degree relatives. Methods In this cross-sectional study, fasting plasma glucose (FPG), oral glucose toler-ance, insulin and C-peptide(CP) were measured in 58 first-episode drug-naive patients with schizophrenia, 22 their first-degree relatives and 24 healthy subjects. Results The morbility of impaired glucose metabolism in pa-tients was 48.3%, which was significantly higher than that in first-degree relatives and healthy subjects, respec-tively (P<0.01). And the level of OGTT 2 h plasma glucose (2 hPG) was similar results also (schizophrenic : 8.51 ±2.05 mmol/L; first-degree relatives:5.61±1.38 mmol/L; healthy subjects:5.88±1.21 mmol/L). In addi-tion, compared with controls, the patients with schizophrenia had significantly higher levels of fasting plasma insu-lin (19.18±7.92 mU/L vs 14.51±6.87 mU/L) ,OGTT 2h plasma insulin(76.83±36.65 mU/L vs 55.05±26.91 mU/L), fasting C-peptide (472.44±167.69 pmol/L vs 324.27±160.23 pmol/L) ,insulin resistance in-dex(4.56±2.05 vs 3.24±1.55), However, fasting plasma glucose had no significant difference among three groups. Conclusion Impaired glucose metabolism is highly prevalent in first-episode patients with schizophrenia. Key words: Schizophrenia,First episode; First-degree relatives; Glucose metabolism