Abstract
[ 3H]-estradiol-17β was incubated with endometrium obtained at different times during the menstrual cycle. The percentage of the [ 3H]-estradiol-17β metabolized was measured. Secretory endometrium metabolizes estradiol-17β at a greater rate than proliferative endometrium. Proliferative endometrium metabolizes estradiol-17β to estrone while secretory endometrium, under the influence of progesterone, metabolizes estradiol-17β to water soluble metabolites and a small quantity of estrone. The production and excretion of water soluble metabolites by the secretory endometrium is rapid. Endometrium showing cystic hyperplasia or adenocarcinoma metabolizes estradiol-17β at the same rate as proliferative endometrium.
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