Abstract
Amorphous meprobamate N-glucuronide, a metabolite of meprobamate which was reported in the previous paper was converted to crystalline sodium salt and the structure was reconfirmed to be sodium meprobamate N-mono-β-D-glucopyranosiduronate. It was also proved that ethinamate (1-ethynylcyclohexylcarbamate) formed the corresponding N-glucuronide in rabbits after dosing the drug. Therefore it could be concluded that N-glucuronide formation might be one of the metabolic pathways in animal body for the drug possessing a carbamate group, although it was not the case for urethane which decomposed almost completely in animal body.
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