Abstract
In a previous paper, it was reported that in rats treated chronically with ethanol, the side-chain oxidation of hexobarbital, N-demethylation of aminopyrine and /?-hydroxylation of aniline in vitro from either 9,000 g supernatant fraction of liver homogenates or washed microsomes was identical with that of control rats when ethanol was withdrawn and substituted for tap water 24 hr prior to sacrifice. In contrast, the activity of aniline hydroxylase of the rats which continued to ingest ethanol ad libitum up to the time of sacrifice was approx. 1.5-fold increased, compated with that of controls, in spite of no change being detected in hexobarbital oxidase and aminopyrine demethylase activities (1, 2).
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