Metabolism of Drugs and Other Foreign Compounds by Enzymatic Mechanisms

Abstract

The duration of drug action is generally limited by the rate of conversion of therapeutic agents to inactivate metabolites, since most drugs must be metabolized before they are excreted in urine, air or bile. Without mechanisms for the metabolism of foreign compounds, little of our present drug therapy would be possible, for many therapeutic agents would evoke their effects for too long a time; in fact, many drugs like chlorpromazine or thiopental would act for virtually a lifetime.KeywordsDrug MetabolismLiver MicrosomeMicrosomal EnzymeBenzyl ChlorideEnzymatic MechanismThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.