Abstract

The metabolism of phenyltin compounds in the rat liver following oral administration of diphenyltin, one of the metabolites of triphenyltin, has been examined. The phenyltin concentrations in the liver were determined by gas chromatography. The concentrations were measured periodically for 72 h after a single oral dose of diphenyltin dichloride was given to rats. We detected not only mono- and diphenyltin but also triphenyltin in the liver, and these compounds were confirmed by gas chromatography-mass spectrometry/selected ion monitoring. No triphenyltin was detected in untreated rat liver to which diphenyltin was added directly

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