Abstract

The metabolism of the pyrethroid insecticide deltamethrin (DTM), labeled on either the alcoholic moiety or on the acid moiety, has been studied in two cultured cell types: Dunaliella, an algae, and mouse fibroblasts. DTM was not metabolized within algal cells and fibroblasts, but was partially transformed into less or not active isomers. In algae and fibroblasts culture media, many metabolites resulting mostly from hydrolysis of the molecule were found. This metabolism seemed to be linked to the release of enzymes by cells into their culture medium. The isomerization of DTM also occurred in the culture media: this could be explained by the interaction of DTM with some constituents of the culture medium.

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