Abstract
The metabolism of sodium dipropylacetate (a newly developed anticonvulsant) was investigated in rats, and two metabolites were found in urine of rats which received dipropylacetate. The metabolites were identified as 2-n-propyl-5-hydroxypentanoic acid and 2-n-propylglutaric acid, respectively, by low and high resolution mass spectrometry. Synthetic 2-n-propylglutaric acid, when administered to rats, was not oxidized further and was excreted intact in urine. These data clearly show that ω-oxidation is involved in the metabolism of sodium dipropylacetate and that 2-n-propylglutaric acid, the end product of ω-oxidation, does not serve as a substrate for β-oxidation.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
