Abstract
TLC and liquid scintillation spectrometry were used to determine the identities and relative quantities of aspirin and its metabolites in the gastric juice, blood plasma, rumen (non- glandular portion), and corpus (glandular portion) of the rat stomach 4min. after the oral administration of aspirin-7-14C. It was found that aspirin and salicylic acid are the major components in the gastric juice, blood plasma, and rumen and corpus tissues. Trace levels of a compound with an Rce_ value corresponding to that of salicyluric acid was found in the fluids and tissues analyzed. No glucuronide conjugates of salicylic acid or polyhy- droxy metabolites of aspirin were found. The level of salicylic acid was fourfold higher in the corpus tissue than in the rumen tissue.
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