Metabolism of alkyl glyceryl ethers in the rat

Abstract

The metabolism of(14)C- and(3)H-labeled alkyl glyceryl ethers after intraperitoneal injections was examined in the liver and intestine of the rat. Additionally, in vitro experiments were conducted with intestinal homogenates and intetinal contents.From these investigations it was concluded that the liver and the intestine metabolize the alkyl glyceryl ethers very differently. Intestinal contents can alter alpha-batyl alcohol, as indicated by preliminary experiments, and intestinal cells contain enzyme systems which convert the alkyl glyceryl ethers to the mono- and di-acyl derivatives. Very little esterified glyceryl ethers were found in the liver lipids. The intestine contains an enzyme system which, although it has a greater specificity for chain length and for isomeric position of the ether than that of the liver system, does cleave the glyceryl ethers.From in vivo studies, of intestinal tissue it was concluded that all of the injected glyceryl ethers were converted intact the ethanolamine, serine, and choline alkyl glyceryl ether phospholipids; with the use of alpha-batyl alcohol, the phosphatidyl ethanolamine fraction, contained most of the labeled glyceryl ether phospholipid with beta-batyl alcohol, alpha-chimyl, and beta-chimyl alcohols, the phosphatidyl, choline fraction contained most of the labeled alkyl glyceryl ether phospholipid. No significant amount (<1%) of labeled alkyl glyceryl ether phospholipids was found in any of the rat-liver lipids.