Abstract
The metabolism of acid mucopolysaccharides in Novikoff hepatoma and in hepatoma BW7756 was studied using the precursors -35S-sulfate, -H-glucosamine and -14C-galactosamine. There is an active formation of sulfated mucopolysaccharides at the mitochondria and cell membrane level. Hepatoma cells synthesize heparin to a lower rate than liver cells. In ascitic as well as in solid tumors there is a considerable accumulation of hyaluronic acid which does not seem to be elicited by the tumor cells but by the surrounding tissues. The possible implication of the low heparin production in the cell membrane characteristics is discussed.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
