Abstract
Incubation of bovine brain microvessel endothelial cell monolayers with the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine led to the monoamine oxidase (MAO)-mediated formation of the oxidative metabolites 1-methyl-4-phenyl-2,3-dihydropyridine and 1-methyl-4-phenylpyridine (MPP +). The flux of the low nanomolar concentrations of [ 3H]MPP + across endothelial cell monolayers appeared to be restricted, probably due to the oxidation by MAO. [ 3H]MPP + did not significantly cross endothelial cell monolayers.
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