Abstract
The metabolism of ornithine and putrescine was studied in vivo in chronically uremic and control rats. Rats were injected intraperitoneally with 1- 14C-ornithine or 1,4- 14C-putrescine and expired 14CO 2 was collected for 4 hr. After injection of 1- 14C-ornithine, 14CO 2 expiration was decreased in uremic rats as compared to controls. Conversely, after 1,4- 14C-putrescine injection, expiration of 14CO 2 was increased in uremic rats as compared to controls. Four hours after the injection of 1- 14C-ornithine, there was more radioactivity in liver and muscle and less radioactivity in kidney of uremic rats as compared to the respective sources in control rats. In uremic rats, 4 hr after the 1,4- 14C-putrescine injection, the radioactivity retained in the muscle and plasma was greater than in corresponding sources in control rats; whereas the radioactivity retained in uremic liver and kidney was similar to that of control rats. The greater putrescine-derived radioactivity retained in uremic tissues reflects either the retention of injected tracer compounds, or retention or decreased catabolism of putrescine metabolites. From 14CO 2 expiration data obtained, it appears that ornithine catabolism is reduced while putrescine catabolism is increased in uremia.
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