Abstract
The incorporation of glucose into the hexosamine moieties of cartilage mucopolysaccharides has been studied. Isotope appears in the galactosamine moiety of the light mucoprotein fraction first and rapidly disappears from this fraction with an accompanying appearance of isotope in the insoluble residue. Chondroitin sulfate accounts for about 80% of the total polysaccharide and appears to be relatively inert metabolically. Appearance of label in chondroitin sulfate prior to keratosulfate suggests that these polysaccharides do not represent part of the same macromolecular structure. This latter point is not established. The effect of several hormones on the incorporation and turnover of isotope in this tissue was also reported.
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