Abstract
1. 1. To analyze the effects of pressure and gas composition on thermoregulation, guinea pigs were exposed to 10–60 atm breathing O 2 and H 2 (hydrox), O 2 and He (heliox), or O 2, N 2 and He (N 2-trimix), at 26–36°C. 2. 2. There were significant differences ( P < 0.001) in O 2 consumption rate (V̇O 2) as a function of chamber and colonic temperature, pressure, and body surface area in the three gas mixtures. 3. 3. There was a significant correlation ( P < 0.001) between V̇O 2 and pressure in heliox but not in hydrox or N 2-trimix; we speculated that the absence of pressure effects is associated with hyperbaric narcosis.
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