Abstract
BackgroundObesity is one of the most common nutritional disorders in dogs and cats and is related to the development metabolic comorbidities. Weight loss is the recommended treatment, but success is difficult due to the poor satiety control. Yeast beta-glucans are known as biological modifiers because of their innumerable functions reported in studies with mice and humans, but only one study with dogs was found. This study aimed to evaluate the effects of a diet supplemented with 0.1% beta-glucan on glucose, lipid homeostasis, inflammatory cytokines and satiety parameters in obese dogs. Fourteen dogs composed three experimental groups: Obese group (OG) with seven dogs with body condition score (BCS) 8 or 9; Lean group (LG) included seven non-obese dogs with a BCS of 5; and Supplemented Obese group (SOG) was the OG dogs after 90 days of consumption of the experimental diet.ResultsCompared to OG, SOG had lower plasma basal glycemic values (p = 0.05) and reduced serum cholesterol and triglyceride levels. TNF-α was lower in SOG than in OG (p = 0.05), and GLP-1 was increased in SOG compared to OG and LG (p = 0.02).ConclusionThese results are novel and important for recognizing the possibility of using beta-glucan in obesity prevention and treatment.
Highlights
Obesity is one of the most common nutritional disorders in dogs and cats and is related to the development metabolic comorbidities
At 5, 7.5 and 10 minutes, blood glucose values were lower in Lean group (LG) than in Obese group (OG) but were not different from those in Supplemented Obese group (SOG)
After 45 minutes, blood glucose levels had returned to baseline only in LG but not in OG or SOG, even after 120 minutes of testing
Summary
Obesity is one of the most common nutritional disorders in dogs and cats and is related to the development metabolic comorbidities. This study aimed to evaluate the effects of a diet supplemented with 0.1% beta-glucan on glucose, lipid homeostasis, inflammatory cytokines and satiety parameters in obese dogs. Beta-glucans are polysaccharides composed of glucose monomers that are linked by β-glycosidic bonds These polysaccharides are the major structural components of the cell wall of yeasts, fungi and some bacteria. Due to its complex mechanism of action in the body, several effects have already been associated with beta-glucan supplementation in humans, pigs, dogs, rats and fish such as modified immune responses [20, 21], reduced inflammatory responses [22,23,24], altered glucose [25, 26] and lipids [26, 27] metabolism
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