Abstract
Background: High uptake of F18-fluorodeoxyglucose parameters for glucose metabolism is related to shorter survival in sinonasal tract cancer with various histological classifications. We investigated whether F18-fluorodeoxyglucose uptake parameters are associated with survival outcomes for patients with only squamous cell carcinoma (SCC) in the sinonasal tract that are treated either with surgery or nonsurgery. Methods: We retrospectively observed F18-fluorodeoxyglucose uptake parameters on positron emission tomography with computed tomography for the primary tumour of SCC in 39 patients. Log-rank test or a Cox regression model with 95% confidence interval (95%CI) and hazard ratio (HR) were used for monovariable or multivariable analysis, respectively. We determined cut-off values of the F18-fluorodeoxyglucose uptake parameters using the lowest p value for monovariable sinonasal tract cancer-specific survival analysis. Results: Monovariable analysis showed that patients with metabolic tumour volume (MTV) ≥ 21.8 had a shorter cancer-specific, disease-free and local recurrence-free survival than those with MTV < 21.8. After adjusting for age, gender, clinical stage and treatment group in the multivariable analysis, MTV (≥21.8/<21.8) was related to shorter cancer-specific (HR: 3.69, 95%CI: 1.17–12.0), disease-free (HR: 3.38, 95%CI: 1.19–9.71) and local recurrence-free (HR: 5.42, 95%CI: 1.59–20.3) survivals. Conclusions: MTV as advances in diagnostics of sinonasal tract SCC is a predictor.
Highlights
Squamous cell carcinoma (SCC) in the sinonasal tract is definitively treated by surgery or radiotherapy with or without chemotherapy [1]
We previously reported that a Charlson comorbidity index ≥6 in 79 patients with sinonasal tract squamous cell carcinoma (SCC) predicted shorter both overall survival (OS) and distant metastasis-free survival (DMFS) after various definitive treatments [9] and that gross tumour volume in 24 patients was a predictor of both local recurrence-free survival (LRFS) and disease-free survival (DFS) after chemoradiotherapy [10]
The aim of the present study was to research whether volumetric parameters on F18-FDG-positron emission tomography with computed tomography (PET/CT) are a predictor of survival outcomes in patients with sinonasal tract SCC who undergo various definitive treatments
Summary
Squamous cell carcinoma (SCC) in the sinonasal tract is definitively treated by surgery or radiotherapy with or without chemotherapy [1]. The aim of the present study was to research whether volumetric parameters on F18-FDG-PET/CT are a predictor of survival outcomes in patients with sinonasal tract SCC who undergo various definitive treatments. We investigated whether F18-fluorodeoxyglucose uptake parameters are associated with survival outcomes for patients with only squamous cell carcinoma (SCC) in the sinonasal tract that are treated either with surgery or nonsurgery. Results: Monovariable analysis showed that patients with metabolic tumour volume (MTV) ≥ 21.8 had a shorter cancer-specific, disease-free and local recurrence-free survival than those with MTV < 21.8. After adjusting for age, gender, clinical stage and treatment group in the multivariable analysis, MTV (≥21.8/
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