Abstract
AbstractThe metabolism of the non‐psychotropic cannabinoid (3R, 4R)Δ1(7)‐tetrahydrocannabinol (1) (=Δ 1(7)‐THC) was investigated in a rat liver microsomal preparation. The metabolites obtained from the incubation mixture were separated, purified and identified by 1H‐NMR. spectroscopy and combined gas‐liquid chromatography/mass spectrometry. Metabolites 3–10 are derived from Δ1(7)‐THC (1) by mono‐hydroxylation in the isoprenoid moiety or the side chain of the molecule. Metabolites 11–16 are hydroxylated in the isoprenoid ring and the side chain simultaneously. The third group, metabolites 18–22, is derived from the 1,7‐epoxide 17 by hydrolysis of the oxirane ring, three of these metabolites bearing additional hydroxyl‐groups in the isoprenoid part or the side chain. The mass spectra of the metabolites are discussed in detail and a new rule for the fragmentations of tetrahydrocannabinols is presented.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
