Abstract
BackgroundThe purpose of this study is to investigate the association of metabolic syndrome (MS) and its components with the risk of impaired glucose tolerance (IGT) in high risk urban professionals. The goal is to improve the selection of candidates who would most benefit from an oral glucose tolerance test (OGTT).MethodsThis is a cross sectional study in which MS was identified by both the definitions proposed by the National Cholesterol Education Program (NCEP) and the International Diabetes Federation (IDF).ResultsThere were 928 eligible subjects in the study, and 23.9% of them failed in OGTT. The odds ratio of IGT was increased 3.16-fold for MS defined by the NCEP criteria and 2.79-fold for the hyperglycemia factor alone. Both MS and hyperglycemia were shown to be acceptable measures to discriminate subjects with IGT from those with normal glucose tolerance (NGT). The clustering of any 1, 2, or ≥3 metabolic components resulted in increased odds ratios for IGT: i.e., 1.71, 2.38 and 5.92, respectively. Even without hyperglycemia in the cluster, an increased odds ratio was still observed. The risk of IGT increased dramatically when the fasting plasma glucose and waist circumference were both at their highest defined level.ConclusionsMS and its components are associated with the increased risk of IGT. People with MS, one of its components, especially hyperglycemia and central obesity, or a cluster of its components are strong candidates for an OGTT in order to achieve early cost-effective detection of IGT.
Highlights
The purpose of this study is to investigate the association of metabolic syndrome (MS) and its components with the risk of impaired glucose tolerance (IGT) in high risk urban professionals
When compared to oral glucose tolerance test (OGTT), the components of MS – measures of waist circumference (WC), blood pressure (BP), fasting plasma glucose (FPG), high-density-lipoprotein-cholesterol (HDL-C) and triglycerides (TG) levels – are far more widely gathered during routine checkups. Given these circumstances, it is useful to evaluate the association between MS and IGT cross-sectionally, in order to improve the selection of candidates who would most benefit from an OGTT
Blood samples were taken after a fast of at least 12 hours and were measured in the clinical laboratory of Beijing Hospital, where the analyses were calibrated by Cholesterol Reference Method Laboratory Network (CRMLN) Member Laboratory (The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health)
Summary
The purpose of this study is to investigate the association of metabolic syndrome (MS) and its components with the risk of impaired glucose tolerance (IGT) in high risk urban professionals. When compared to OGTT, the components of MS – measures of waist circumference (WC), blood pressure (BP), fasting plasma glucose (FPG), high-density-lipoprotein-cholesterol (HDL-C) and triglycerides (TG) levels – are far more widely gathered during routine checkups. Given these circumstances, it is useful to evaluate the association between MS and IGT cross-sectionally, in order to improve the selection of candidates who would most benefit from an OGTT. In China, the probability of IGT given MS is usually underestimated by clinicians when evaluating patients with normal fasting glucose levels
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