Metabolic syndrome and risk factors for atherosclerotic diseases in reproductive aged females

Abstract

Background and Aims : Abdominal obesity, insulin resistance (IR), hyperinsulinemia (HI), dyslipidemia, arterial hypertension (AH), impaired glucose tolerance, hyperuricemia, polycystic ovary syndrome (POS) and hyperandrogenemia - are established cardiovascular risk factors. Purpose: to study risk factors for atherosclerotic diseases in reproductive aged women.Methods: A total of 1786 people (598 adolescent females and 1188 reproductive aged women) with suspected MS were examined. As a result of the screening, a group of 306 people (92 adolescents and 214 reproductive women) were selected for an in-depth study for components of MS.Results: In adolescent girls hypoalphacholesterolemia (34%), hypercholesterolemia (27%), hypertriglyceridemia (21%), overweight and obesity (59%), cystic enlarged ovaries (58%), hyperuricemia (59%) were noted. In women of reproductive age hypertriglyceridemia (58%), hypercholesterolemia (35%) and hypoalphacholesterolemia (34%), overweight and obesity (66%), AH (46%), hyperuricemia (41%) were noted. In reproductive women there was a decrease of sex hormone binding globulin (SHBG) regardless of obesity. The value of SHBG less than 60 nmol/l was observed in 79% of patients with MS. In patients of reproductive age with a sedentary lifestyle and predominance of fatty foods in the diet, the incidence of IR and HI increases, which is not a leading factor. The absence of a statistically significant effect of smoking on metabolic parameters in women with MS and POS may be due to the powerful effect of other factors, primarily genetic IR.Conclusions: The high frequency of MS among women of reproductive age necessitates their mandatory examination for IR, HI and associated disorders, as cardiovascular risk factors. Social factors can contribute to MS manifestations. Background and Aims : Abdominal obesity, insulin resistance (IR), hyperinsulinemia (HI), dyslipidemia, arterial hypertension (AH), impaired glucose tolerance, hyperuricemia, polycystic ovary syndrome (POS) and hyperandrogenemia - are established cardiovascular risk factors. Purpose: to study risk factors for atherosclerotic diseases in reproductive aged women. Methods: A total of 1786 people (598 adolescent females and 1188 reproductive aged women) with suspected MS were examined. As a result of the screening, a group of 306 people (92 adolescents and 214 reproductive women) were selected for an in-depth study for components of MS. Results: In adolescent girls hypoalphacholesterolemia (34%), hypercholesterolemia (27%), hypertriglyceridemia (21%), overweight and obesity (59%), cystic enlarged ovaries (58%), hyperuricemia (59%) were noted. In women of reproductive age hypertriglyceridemia (58%), hypercholesterolemia (35%) and hypoalphacholesterolemia (34%), overweight and obesity (66%), AH (46%), hyperuricemia (41%) were noted. In reproductive women there was a decrease of sex hormone binding globulin (SHBG) regardless of obesity. The value of SHBG less than 60 nmol/l was observed in 79% of patients with MS. In patients of reproductive age with a sedentary lifestyle and predominance of fatty foods in the diet, the incidence of IR and HI increases, which is not a leading factor. The absence of a statistically significant effect of smoking on metabolic parameters in women with MS and POS may be due to the powerful effect of other factors, primarily genetic IR. Conclusions: The high frequency of MS among women of reproductive age necessitates their mandatory examination for IR, HI and associated disorders, as cardiovascular risk factors. Social factors can contribute to MS manifestations.