Abstract
Psoriasis in adults is associated with an increased risk of metabolic disease. Various cardiometabolic comorbidities have been reported in childhood psoriasis, but only a few studies have analyzed the prevalence of metabolic syndrome. We performed a single-center prospective study investigating the prevalence of metabolic syndrome and insulin resistance in children with psoriasis. The prevalence of metabolic syndrome was evaluated in 60 pre-pubertal children with psoriasis (age: 3–10 years), accordingly to recently established criteria for the diagnosis of metabolic syndrome in children. Insulin resistance was considered altered when the homeostatic model assessment (HOMA-IR) for insulin resistance was ≥ 90th sex- and age-specific percentile and HOMA 2-IR was > 1.8. Eighteen (30%) children with psoriasis were found to have metabolic syndrome. Sixteen (27%) children were found to have insulin resistance.Conclusion: Our data underline the importance of assessing metabolic syndrome not only in adults and adolescents but also in young children with psoriasis.What is Known:• Psoriasis in adults is strongly associated with metabolic disease and insulin resistance.• Very limited data are available on the prevalence of metabolic syndrome and insulin resistance in pre-pubertal children with psoriasis.What is New:• This study reports that in pre-pubertal children with psoriasis, there is a high prevalence of metabolic syndrome and insulin resistance.• In children with psoriasis metabolic syndrome risk factors should be assessed.
Highlights
This study reports that in pre-pubertal children with psoriasis, there is a high prevalence of metabolic syndrome and insulin resistance
Few data are available about this topic in children with psoriasis as most of the available studies analyze the prevalence of only single components of metabolic syndrome (MetS) [5,6,7,8,9] and not the overall prevalence of MetS [9]
The following data were collected for each patient by the same team of dermatologists experienced in pediatric dermatology: age, sex, height, body weight, body mass index (BMI), systolic and diastolic blood pressure (BP), waist circumference (WC), waist-to-height ratio (WHtR), and family history of psoriasis and metabolic or cardiovascular diseases
Summary
Psoriasis in adults is associated with an increased risk of metabolic syndrome (MetS) [1,2,3,4].Few data are available about this topic in children with psoriasis as most of the available studies analyze the prevalence of only single components of MetS [5,6,7,8,9] and not the overall prevalence of MetS [9].The few studies on MetS in childhood psoriasis evaluated only a small number of children and a still more limited number of young children [10,11,12].We performed a single-center study, investigating the prevalence of MetS and levels of insulin resistance in a population of pre-pubertal children with psoriasis and the correlations with clinical and anamnestic data. Psoriasis in adults is associated with an increased risk of metabolic syndrome (MetS) [1,2,3,4]. Few data are available about this topic in children with psoriasis as most of the available studies analyze the prevalence of only single components of MetS [5,6,7,8,9] and not the overall prevalence of MetS [9]. The few studies on MetS in childhood psoriasis evaluated only a small number of children and a still more limited number of young children [10,11,12]. We performed a single-center study, investigating the prevalence of MetS and levels of insulin resistance in a population of pre-pubertal children with psoriasis and the correlations with clinical and anamnestic data
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
