Abstract
BackgroundPrior studies reported conflicting findings on the association between metabolic syndrome and inflammatory biomarkers. We tested the cross-sectional associations between metabolic syndrome and nine inflammatory markers.MethodsWe measured C-reactive protein, CD40 ligand, interleukin-6, intercellular adhesion molecule-1, monocyte chemoattractant protein-1, osteoprotegerin, P-selectin, tumor necrosis factor-alpha, and tumor necrosis factor receptor-2 in 2570 Framingham Offspring Study participants free of diabetes and cardiovascular disease at examination 7. Metabolic syndrome was defined by National Cholesterol Education Program criteria. We performed multivariable linear regressions for each biomarker with metabolic syndrome as the exposure adjusting for age, sex, smoking, aspirin use, and hormone replacement. We subsequently added to the models components of the metabolic syndrome as continuous traits plus lipid lowering and hypertension treatments. We considered P < 0.05 as statistically significant.ResultsMetabolic syndrome was present in 984 (38%) participants and was statistically significantly associated with each biomarker (all P < 0.02) except osteoprotegerin. After adjusting for its component variables, the metabolic syndrome was associated only with P-selectin (1.06 fold higher in metabolic syndrome, 95% CI 1.02, 1.10, p = 0.005).ConclusionsMetabolic syndrome was associated with multiple inflammatory biomarkers. However, adjusting for each of its components eliminated the association with most inflammatory markers, except P-selectin. Our results suggest that the relation between metabolic syndrome and inflammation is largely accounted for by its components.
Highlights
Prior studies reported conflicting findings on the association between metabolic syndrome and inflammatory biomarkers
Regression model for the individual markers Multiple linear regression models demonstrated highly statistically significant associations (P
Our study evaluated a panel of nine inflammatory biomarkers in a moderately large-sized cohort, and supports the hypothesis that metabolic syndrome as a construct generally is not more than the sum of its parts with respect to inflammation
Summary
Prior studies reported conflicting findings on the association between metabolic syndrome and inflammatory biomarkers. We tested the cross-sectional associations between metabolic syndrome and nine inflammatory markers. An association between metabolic syndrome and an elevated risk of developing. According to the most recent World Health Organization expert consultation with respect to metabolic syndrome, future research should focus on further elucidation of common metabolic pathways underlying the development of diabetes and cardiovascular diseases [13]. Prior studies have examined the association of metabolic syndrome to one or a few inflammatory biomarkers, in modest-sized cohorts reporting conflicting findings [2,9,10,12,16]. The available literature has been inconclusive as to whether metabolic syndrome is a better predictor of the development of diabetes mellitus and/or cardiovascular disease when compared to its individual factors. Some experts have suggested that the risk associated with the syndrome is explained by the presence of its components [17,18,19]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
