Abstract
It is unknown whether the presence of metabolic syndrome (MetS) affects the incidence of laryngeal cancer. The aim of this national population-based retrospective study was to analyze the relationship between MetS and the incidence of laryngeal cancer. Patients with laryngeal cancer (ICD-10: C32) between 2009 and 2010 were retrospectively identified and tracked until 2015 using the Korean Health Insurance claims database. During the seven-year follow-up period, 5,322 subjects were newly diagnosed with larynx cancer. The mean age of people with laryngeal cancer was much higher than those without (63.29 vs. 47.7 years, p < 0.0001), and the incidence of larynx cancer in men was much higher than that in women (93.16% vs. 6.84%, p < 0.0001). Age, gender, smoking status, alcohol intake, and exercise-adjusted hazard ratios indicated that participants with MetS had a 1.13-fold higher hazard of having larynx cancer than those without MetS. The number of MetS components was a strong risk factor for laryngeal cancer with a higher risk estimate of this cancer in both ex- and current smokers as well as people who have never smoked. MetS was found to be an independent risk factor for the incidence of laryngeal cancer. In Korea, MetS and its components are significantly associated with the development of laryngeal cancer.
Highlights
Nearly 10,000 people are newly diagnosed as laryngeal cancer which is one of the most common cancer of the upper aerodigestive tract[1]
We examined the joint effect of smoking and the number of metabolic syndrome (MetS) components at baseline on the risk of laryngeal cancer (Table 3)
In multivariable analyses subjects with the following three combinations had the highest hazard ratio (HR) of having larynx cancer: (1) abdominal obesity, elevated blood pressures (BP), and elevated fasting blood glucose (FBG) (HR, 1.325; 95% confidence interval (CI), 1.130–1.554); (2) elevated FBG, elevated BP, and elevated TG (HR, 1.129; 95% CI, 1.055–1.409); and (3) elevated TG, elevated FBG, and low high-density lipoprotein (HDL) cholesterol (HR, 1.357; 95% CI, 1.1073–1.664)
Summary
Nearly 10,000 people are newly diagnosed as laryngeal cancer which is one of the most common cancer of the upper aerodigestive tract[1]. Metabolic syndrome (MetS) is associated with an increased risk of the development or progression of cancer. The prevalence of MetS has increased worldwide, in parallel with the increasing cancer incidence[2,3]. MetS is strongly associated with the cancer risk and mortality. MetS has been shown to be associated with increased incidences of prostate cancer, colorectal cancer, and the recurrence of breast cancer[7,8,9,10]. In patients with MetS, hormonal disturbances are usually detected, and this hormonal deregulation is presumed as a risk factor for carcinogenesis in prostate, colorectal, and endometrial cancers[11,12,13]. There has not yet been any investigation conducted to reveal the association between MetS and laryngeal cancer. We evaluated the association of larynx cancer with MetS and its individual components in the Korean population
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