Metabolic Syndrome and Colorectal Cancer Risk: Results of Propensity Score-Based Analyses in a Community-Based Cohort Study.

Eun Young Park,Eunjung Park,Jinsun Kim,Min Kyung Lim,Jin-Kyoung Oh,Byungmi Kim

doi:10.3390/ijerph17228687

Abstract

Background: This study aimed to determine the effects of metabolic syndrome (MetS) on colorectal cancer (CRC) using propensity score (PS) methods. Methods: The study subjects were 2417 men and 4568 women from the Korean National Cancer Center (KNCC) Community Cohort enrolled between 2003 and 2010. Odds risks (ORs) and 95% confidence intervals (CIs) using PS matching analysis, regression models adjusted by the PS or stratified into five strata according to PS, and PS weighting methods were calculated. Results: In women, MetS and abnormally high triglyceride (TG) levels were associated with CRC risk using the PS matching analysis (ORs, for MetS, 2.19 (95% CI, 1.10–4.33); for abnormal TG levels, 2.08 (95% CI, 1.07–4.02)). However, there were no significant associations between MetS and TG levels and CRC risk in men. Conclusions: Our study might provide additional evidence that deteriorated metabolic profiles increase the risk of CRC in women rather than men. Thus, this may have an important role in effective population-level interventions for deteriorated metabolic profiles at an early stage.

Highlights

Colorectal cancer (CRC) is the third most common cancer in both sexes worldwide (1,360,602 cases, 9.7% of the total cancer burden)
This study investigated the effect of metabolic syndrome (MetS) on colorectal cancer (CRC) incidence by conducting propensity score (PS)-based analyses considering age, alcohol consumption, smoking, high animal fat intake, obesity, a lack of dietary fiber intake, and a lack of physical activity, etc., which have been identified as modifiable risk factors for CRC [12,13,14,15,16,17,18,19], in a community-based prospective cohort in the Republic of Korea
There were 57 men and 54 women newly diagnosed with CRC after the entry of this cohort and their median follow-up years were 4.76 (IQR, 2.91–7.79) for men and 5.55 (IQR, 3.06–7.53) for women, respectively

Summary

Introduction

Colorectal cancer (CRC) is the third most common cancer in both sexes worldwide (1,360,602 cases, 9.7% of the total cancer burden). This study aimed to determine the effects of metabolic syndrome (MetS) on colorectal cancer (CRC) using propensity score (PS) methods. Results: In women, MetS and abnormally high triglyceride (TG) levels were associated with CRC risk using the PS matching analysis (ORs, for MetS, 2.19 (95% CI, 1.10–4.33); for abnormal TG levels, 2.08 (95% CI, 1.07–4.02)). There were no significant associations between MetS and TG levels and CRC risk in men. Conclusions: Our study might provide additional evidence that deteriorated metabolic profiles increase the risk of CRC in women rather than men. This may have an important role in effective population-level interventions for deteriorated metabolic profiles at an early stage

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